A recent issue of Science (May 23) titled “Microbial Worlds” had an article on sponges on page 1028. Apparently, multiple, unrelated species of sponges produce a chemical called manzamine A that has anti-malarial properties reported to be more efficient than chloroquine or artemisinin at killing parasites. The chemical is actually produced by a certain bacteria that grows on sponges.

This is the most recent review I found:

Curr Pharm Des. 2007;13(6):653-60